持续滴注氟尿嘧啶治疗恶性肠梗阻
2016-11-1 来源：不详 浏览次数：次Continuous5-fluorouracilinfusionformalignantbowelobstruction
duetoperitonealdisseminationfromgastriccancer
Shou-meiYang,Hao-binYu,Qi-yuanXu,Shi-weiLi,Wei-weiLiu,Xing-Liu,Su-yiLi*
DepartmentofMedicalOncology,AnhuiProvincialCancerHospital,AnhuiMedicalUniversity,HuanhuRoadEast,Hefei,,PeoplesRepublicofChina
*Correspondingauthor:ProfessorSu-yiLi,DepartmentofMedicalOncology,AnhuiProvincialCancerHospital,AnhuiMedicalUniversity,HuanhuRoadEast,Hefei,,PeoplesRepublicofChina
Objective：TheaimofthisstudywastoevaluatetheefficacyandsafetyofContinuous5-fluorouracilinfusioninmalignantbowelobstructionduetoperitonealdisseminationfromgastriccancer.
Methods:Twenty-forgastriccancerpatientsdiagnosedwithmalignantbowelobstructionduetoperitonealdisseminationweretreatedwithcontinuous5-FUinfusion(mg/m2daily)d1-5,8-12,q3w.Theprimaryendpointwassymptomcontrol(remissionofobstruction).Thesecondaryendpointwasthesymptomcontroltimeandsurvival,andthetertiaryendpointwasadverseeffects.
Results:Twenty-fourpatientsunderwentthetreatment.Pretreatment,18/24patients(75.0%)werenilperos,6/24(25.0%)drankliquids.Aftercontinuous5-fluorouracilinfusion,only4/24(16.7%)wasstillnilperos,4/24(16.7%)drankliquids,5/24(20.8%)atesoftsolids,and11/24(45.8%)ateafulldiet.Theimprovementinabilitytoeatusingthescoringsystemwasstatisticallysignificant(p0.).MedianremissiontimeofMBOwas.0days.Mediansurvivalwasdays.Three-monthsurvivalratewas54.2%andsix-monthsurvivalratewas45.8%.Treatmentwaswelltolerated,withgradeIIItoxicitiesconsistingofthrombocytopeniain2patient(8.3%),andmucositisin3patient(12.5%).
Conclusions:Continuous5-FUinfusioniswelltoleratedandshowsactivityinmalignantbowelobstructionduetoperitonealdisseminationfromgastriccancer.Continuous5-FUinfusionprovidesarationaleforexploringthisassociationinthefuture.
KeyWords:GastricCancer,Malignantbowelobstruction,peritonealdissemination,Chemotherapy,5-fluorouracil
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